Gleevec and Skin-Gleevec is NOT Chemo

2008-05-31 20:13:26

Hey Chris,
If it walks like a chicken and looks like a chicken it must be
one. .. In other words anything that kills cancer cells on a daily
basis is a chemo friend of mine.
I am also big on (sun based) Vit D for people like myself. I had a
dark complexion which is now normal (not white) and I intend to get
10 or so minutes of sun daily this spring and summer in off peak
hours to keep my vitamin D and spirits up. I never get red in the sun
since I am careful when I get out there. This will be my sixth summer
of enjoying the sun before 10 and after 4. if I venture out in
between I use the sunblock.
Wayne

Gleevec and Skin-Gleevec/ chris

2008-05-31 08:41:35

HAHAHA!! Thanks for that post!
-shalyn

Gleevec and Skin-Gleevec is NOT Chemo

2008-05-31 00:46:56

Hey,
I have noticed a lot of chickens with bad hair days
lately. Let stop ruffling and let that "down" keep
your bottoms warm - its cold out there today!
By the way - My vote is for Gleevec being Chemo
therapy! As well I cast a vote for Meatball Pizza
this Friday!
Love and Mercy!

Re: Gleevec and Skin-Gleevec is NOT Chemo

2008-05-30 19:35:06

Well,not to ruffle your feathers-okay maybe just a bit;
Gleevec is chemo and I don't know how you think it is not.
Chemotherapy def'n: the treatment of cancer using chemical agents or
drugs that are destructive to malignant(cancerous)cells or tissue.
Seems pretty straight forward to me.

Recently diagnosed

2008-05-30 18:50:15

I am 35, was recently diagnosed with CML and have been on Gleevec for
about two weeks.
My side effects have been minimal. I am experiencing dryness in my
nose and itching on my back. Anyone have this?

Re: [cml 2] Digest Number 623

2008-05-30 04:33:33

Hey Group:
My Hematologist/Oncologist stated that Gleevec's a very benign chemotherapy
treatment I agree, only in comparison to IV chemo; 'cause I went through H**L.
Skin tone changed drastically (hehe~~Tracey). Hair color went shades darker and
lost hair came back . . .gray with change in texture. Skin became thinner and in
addition to rash, developed scalp-nose-ear-eye issues. First time I've ever
maintained long fingernails, can't stand the toenail growth (hehe). Ladies
only~~became completely oblivious to menopause but libido was increased (hehe).
Due to all my chronic Orthopedic issues, I don't know if bone pain was
increased. No appetite, night sweats/chills, nausea/vomiting--trips to bathroom
voiding from all body exits. I am a Survivor--I AIN'T FINISHED YET!
Take care, ALL are in my prayers.
"K"
"I AIN'T FINISHED YET"!!!

Re: my story

2008-05-29 22:08:50

Congratulations, Skip. You're now a "blogger." I enjoyed your
first entry. May I ask you what was the bad reaction you had in the
beginning of AMN-107 treatment?
I like what you said about just being "along for the ride." We
never know what plans God has for us, do we?
Warm regards.
David

Re: Gleevec and Skin

2008-05-29 17:15:08

Hi Siu,
Hypopigmentation (lightening of skin colour) is not a hidden side
effect of Gleevec, but infact, it's a well documented side effect.
Gleevec inhibits an enzyme called c-kit which plays a role in
melanocyte development (this is what gives us our skin colour). This
basically means that our skin doesn't make colour like it used to and
we become more pale. I guess the darker you were to start off with,
the more noticeable it will be. I've always been white but now I'm so
white that if I get any whiter, I'll be see through :).
Because of this whole issue, you need to be very careful in the sun
because you can burn very quickly. When normal people tan, the colour
comes from the melanin in their skin and since our melanin is
inhibited, that means we don't tan but rather burn to a crisp.
There are lots of abstracts on hypopigmentation caused by Gleevec but
here's just one:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=14635084&dopt=Abstract
Take care,
Tracey

Gleevec and Skin

2008-05-29 10:46:22

Hi there,
Does anyone have the same experience with me? I am on 400mg Gleevec
since last September. I notice my skin got lighter in color. My
hands and my face is very noticeable. Somehow, this gives me a pale
look. Maybe I did not expose to much sun in winter?
Another thing with my skin is it gets thinner. Just use my nail to
scratch on my itchy spot, it leaves red scratch marks behind. I have
to be very careful not to get cut and bruises.
It is hidden side effects of Gleevec? Skin lightening and
thinning......lol
Siu

Re: [cml 2] Gleevec and Skin

2008-05-29 10:00:24

Its the Gleevec palor, which is common. Dont go into the sun winter or summer.
Gleevec is chemo and its a no-no.
Your skin probably isnt getting thinner, its probably your platlets. They will
usually stay
lower which causes the red marks.
Denice
cy_butterfly3 <cy_butterfly3@...
Hi there,
Does anyone have the same experience with me? I am on 400mg Gleevec
since last September. I notice my skin got lighter in color. My
hands and my face is very noticeable. Somehow, this gives me a pale
look. Maybe I did not expose to much sun in winter?
Another thing with my skin is it gets thinner. Just use my nail to
scratch on my itchy spot, it leaves red scratch marks behind. I have
to be very careful not to get cut and bruises.
It is hidden side effects of Gleevec? Skin lightening and
thinning......lol
Siu

my story

2008-05-29 06:22:00

Hello Group,
after careful consideration I have put my history on a
web page.. I have asked Zaviem to check it out to see
if it is suitable. I must remind anyone that reads it
that my case is a bit different than most.
So just keep in mind that low counts are ok.. In fact
when I zero platelets Zaviem asked his new doc about
that and she confirmed that low counts do not mean as
much as we all think.
My web page is at
http://easyskip.tripod.com
if you wish just leave a message in the guest book and
I will try to answer all question although I am not
the brightest leaf on the tree.
SkipD
DX'ed when the dead sea was just ill.

Re: Social Security Disability

2008-05-28 17:21:40

Hi.
I was approved for Disability about 6 weeks after I was diagnosed and
unable to work. I was on Gleevec at the time-now I am on
interferon. I did not have any problems receiving it and have not
had any problems with them in the meantimes. I was told that it
would be indefinite as to how long i could remain on it although I
hope to be back at work by summer. I am in Canada and am not sure
where you are not this may not be the case for you.b

Re: [cml 2] Untreated CML better than tolerating treatment???

2008-05-28 13:00:55

I think your father-in-law has CLL (chronic lymphocytic leukemia) and YES,
this is often not treated......and the life span with the disease is about
15 years, so for an elderly patient (which most people with CLL are), that
is about a normal life span.
You need to get this clarfied. With CML and NO treatment, it would be
highly unlikely that you would have a normal white count after 6 months of
no treatment.
Nancy C.

Re: [cml 2] Getting Neupogen paid for - Cam

2008-05-28 07:28:19

Tracey,
Thanks so much for the links. You are an amazing researcher and fund
of knowledge. I will take this form to my doctor tomorrow and get
rolling on it. Again, thanks. I feel so blessed to be part of this
group.
Cam

This email has been scanned by Barracuda Network's Anti-Virus and Spam Firewall.

Getting Neupogen paid for - Cam

2008-05-27 23:40:23

Hi Cam,
I came across this website that seems to indicate that there is a way
you might be able to get Neupogen paid for, even though it's not
considered an approved drug for myeloid cancers in Alberta.
http://www.drugcoverage.ca/p_benefit_ab.asp#3
There's a form your doctor needs to fill out that can be found here:
http://www.ab.bluecross.ca/dbl/pdfs/ahwdbl_sec1_sa.pdf
Hope this helps,
Tracey

Re: Section 8 - Province of Ontario Only

2008-05-27 17:36:40

Wow, thanks for the good news, Zavie. Do you have a link to a news
release or article that talks about this?

Re: Untreated CML better than tolerating treatment???

2008-05-27 15:33:22

Hi.
Frankly, I think you need to get a second opinion and right away. Who
are these doctors who are telling him not to treat the CML? What are
their qualifications?
On this and other discussion boards there are folks in their 70s, who
have had heart and other health issues, who are being treated for
their CML -- just as aggressively as those who are younger. Unless
there's something more to your father-in-law's story (and I can't
imagine what that could be), the advice you've received sounds like
dangerous nonsense to me.
Simply put, CML untreated is a near-certain death sentence, with life
expectancy typically in the 3 to 5 year range. Treated properly by a
hematologist/oncologist who knows what he or she is doing, it is
possible that CML will have little or no effect on mortality .
Just my two cents.
Best of luck and warm regards.
David

Untreated CML better than tolerating treatment???

2008-05-27 06:32:01

My father-in-law has been diagnosed for having CML six months ago. He
is 77 years old, had cardiac by-pass surgery a year ago and is told NOT
to take anything for treatment of CML. He had pleural effusion a month
ago, otherwise, he is managing daily life pretty good. His white blood
count is normal. But he suffers from anaemia and very low red blood
count. He had three blood transfusions so far and doctors keep telling
him that this is the best to do for his age and health condition. Is
this true???? will his case be stabilized (in remission) for a long
time?? what should we expect?

Section 8 - Province of Ontario Only

2008-05-27 00:38:58

For those patients in Ontario, Canada, you will be pleased to know that your
doctor no longer has to complete the Section 8 form in order for you to get
Gleevec. All that is required is for him/her to write a prescription for the
drug.
Zavie

Re:trial/bone metabolism

2008-05-26 16:47:09

Hi Tracey,
I did have my urine tested for protein. I was not losing protein into my
urine. My kidneys were working fine. I just checked my blood report, and the
ALT, AST, and total bilirubin were also fine. My total protein was 4.4 and
my albumin was 2.9. Like I mentioned, I already had an endoscopy/colonoscopy
and a kidney workup. I was sent to a dietician for a high protein diet. I
find it absolutely impossible to eat the high amount of protein that the
gastroenterologist prescribed. I did try. I think my protein intake is within
the normal range. I have "protein losing enteropathy"...losing protein
somewhere...who knows where? Phosphorous was also within the normal range.
Everything on the Hepatic Function report was normal except total protein and
albumin. Should I still be worried about the liver?
I'm also glad they're doing this clinical trial on bone metabolism at MSKCC.
My dr., Ellin Berman, was the first author on the paper published in the
New Eng. Journal of Med. last May. Therefore, she's following it up with the
trial. It doesn't require more visits to the dr. than normal for me, so
joining the study was a "no brainer". I'll let you know how it goes.
Nancy in NY

RE: [cml 2] Do we have access to Sprycel in Canada?

2008-05-26 15:03:05

Hi Cam,
I still go back to my original suggestion for you.
You need to be seen and treated by a CML specialist.
Any and all of the questions that you have been asking on this list should
be answered by your doctor. The longer you wait, the worse your outcome will
be.
Zavie
Zavie Miller (age 68)
67 Shoreham Avenue
Ottawa, Canada, dxd AUG/99
INF OCT/99 to FEB/00, CHF
No meds FEB/00 to JAN/01
Gleevec since MAR/27/01 (400 mg)
CCR SEP/01. #102 in Zero Club
PCRU 5/02 at RVH
2.8 log reduction Sep/05
3.0 log reduction Jan/06
e-mail: zmiller@...
Tel: 613-726-1117
Fax: 309-296-0807
Cell: 613-202-0204

Re: Do we have access to Sprycel in Canada?

2008-05-26 11:17:03

Hi Cam,
I'm sure you'll get more answers but from what I understand, Sprycel
can cause just as much myelosupression as Gleevec and sometimes more
so since it's so much more potent.
It's not available in Canada as an approved drug yet but I'm hoping
that will change soon since it's been available in the US for some
time now.
I don't believe any of the clinical trials are still recruiting
because they expect the drug to be approved very soon but I could be
wrong. Certainly, your doctor should know this.
I know I've said this before but your case is not a "run of the mill"
case and you really should be seeing someone who is very experienced
in CML. I hope you can find someone soon.
Take care,
Tracey

Do we have access to Sprycel in Canada?

2008-05-26 02:39:31

Hello everyone,
After giving it a final shot it appears I have failed Gleevec. My blood counts
refuse to stay
above required thresholds. I need to have a plan B which preferrably is not a
bone marrow
transplant. Is Sprycel availiable in Canada or is it only in clinical trial?
Would I most likely have
the same problem on sprycel or does it bind differently than Gleevec does? If it
is only in
clinical trial does anyone know a trial that is recruiting?
Cam

Re: bone metabolism

2008-05-25 20:13:19

I read the comments about the study which showed Gleevec interferes with
some bone metabolism. I just joined a clinical trial at MSKCC which will
monitor 60 Gleevec patients for just that. I have to have a bone density test
on
Friday, and give a urine and blood sample. Then, I'll be monitored every
three months for any bone metabolism problems. I don't think I have any
problems
with this at the present time. I had a bone density test last year and
everything was fine. The clinical trial will check me closely, however. I
decided to join the trial because if any problems develop, they can be found
early,
and I can be put on meds to help the situation.
I do have one concern, however. My albumin has been low. My hematologist
at MSKCC has asked me to see a gastroenterologist again because of this. I
went to the gastro/onc last year. I had an endoscopy/colonoscopy and
everything was fine. I also had a kidney workup, and everything was fine there
too.
I'm a little worried about some liver damage. Has anyone else had low
albumin levels? Should I be worried about liver damage? There are no other
symptoms of liver problems.
Nancy in NY
dx. 1/04
400 mg.

Re: [cml 2] vision examination

2008-05-25 13:43:05

Hi Margaret I have the same problem with driving,I do all the driving my wife is
legally blind.I'ts not to bad driving because you can see the big stuff,I got a
G P S that talks the drive and has the roads on screen.I can see the screen but
not the street sign.I figured it was water retention.
dxt 12/23/06 400 gleevec good blood count age 65

vision examination

2008-05-25 06:03:14

Can people in the group advise me?
Diagnosed 10-1-06, now on 400 mg gleevec, wbc in normal range.
I have blurry and poor vision but not all the time! It tends to come and go.
How do you get accurate corrective eyeglasses? Much of my work is
reading/writing and it's getting more and more difficult to see the computer
screen and read print material..
I'd appreciate your comments.
Thanks,
Margaret Raymond
Margaret Raymond,
mpraymond@...
margaret-raymond@...

Re: vision examination

2008-05-25 05:07:22

Hi Margaret,
I have the same problem. Most of the time my vision is 20/20 but
occasionally it's not. It's never terrible but it can get a bit
blurry at times, especially in the evenings.
I managed to go to my optometrist one day when it wasn't perfect and
I got a prescription for a pair of glasses. I put them on when I need
to, which thankfully isn't that often. They're not very strong but
they do help when needed.
The best thing I could suggest to you is the next time you feel your
vision is poor, go over to your eye doctor's office and see if you
can be checked for a pair of glasses.
Take care,
Tracey
dx Jan 2002

Re: [cml 2] BMB - New Doctor

2008-05-24 21:15:09

Congrats Zavie on your new Doc
I must admit that my new Doc Doctor Steven Couban
does a great BMB as well and with being on the trial
drug I have to have BMB's every two months so I am
glad all these hematologiest are not like the old ones
My frist BMB was not a pleasant experience but they
seem to get better over the years. Guess it may be
new freezing or something but I no longer mind BMB's
just the thought gives me the willies not the actual
BMB
Hope your as happy with the new doc as you were with
the old...
SkipD
DX'ed 1978

Re: [cml 2] Digest Number 616

2008-05-24 18:53:31

For Skip~~'My Hero':
Per our conversation the other month. . .I'm glad that you decided to 'hang
tough' and keep your 'Survival' available to the 'Newbies' as you did for me.
Love Ya & Kim. . ."K"
"K"
"I AIN'T FINISHED YET"!!!

BMB - New Doctor

2008-05-24 06:51:37

Hi all, and especially those of you in and around Ottawa.
My local hematologist, Dr. Janis Bormanis, is retiring and suggested that I
switch to Dr. Isabelle Bence-Bruckler. I saw her for the first time last
week and after an excellent interview she scheduled me for a BMB today.
It was my opinion that Dr. Bormanis did the best BMBs. Well, after today's
BMB with Dr. Bence-Bruckler, I have a new best BMBer. If Dr. Bormanis was a
9.5 on my scale, then Dr. Bence-Bruckler is a perfect 10. No pain at all.
Not even during the application of the freezing. We chatted throughout the
entire procedure. It was not a great surprise since Dr. Bormanis was her
teacher.
Two samples were taken. One will be analyzed here in Ottawa and the other
will be sent to Dr. Suzanne Kamel-Reid's lab at the PMH in Toronto. This
will confirm whether my last BMB done in Ottawa was really PCRU.
Zavie
Zavie Miller (age 68)
67 Shoreham Avenue
Ottawa, Canada, dxd AUG/99
INF OCT/99 to FEB/00, CHF
No meds FEB/00 to JAN/01
Gleevec since MAR/27/01 (400 mg)
CCR SEP/01. #102 in Zero Club
PCRU 5/02 at RVH
2.8 log reduction Sep/05
3.0 log reduction Jan/06
e-mail: zmiller@...
Tel: 613-726-1117
Fax: 309-296-0807
Cell: 613-202-0204

For Cheryl-Ann

2008-05-24 04:40:56

I don't know what all has been going on with the lists and back biting and I
don't want to know. I just want to tell you that I value and appreciate all the
information you give to us with your writings and am sorry that some people have
gotten so caught up in the thick of thin things. It never fails when you do so
much good for many of us there are those who just can't accept the valuable
resource we have in you and leave it at that. Many thanks from one who
appreciates you. Penny M

Re: Clearing the Air

2008-05-24 00:11:17

Thank you Cheryl-Anne for your great post. I hope
this now settles the air as I, for one of thousands,
appreciate your input.
Thanks.
Judy
Hugs,
Judy P. in Calgary

Re: South African CML'ers

2008-05-23 21:21:25

Hello Iris
I am from South Africa, but in the USA now. I wish I could help you
contact other cml'ers there, but probably the best is to check with
the hospitals if they have support groups? You have probably tried
that already.
Again, wish I could help you with this.
Love
Annie
Steven's mom
livingwithcml.blogspot.com

The List - Part II - Clearing the air

2008-05-23 09:49:51

Dear fellow CMLers,
Grab a cup of coffee or a tea, this is going to be a long one...
First off thanks to the many of you who have written to me privately. I am
will try to answer you all personally, it's going to take time, because my
life is on overload at the moment. This post today is just to clear the air
about a few things, and I want to thank those of you who wrote me and asked
me to do this.
You should know that I have not been reading the list, because I understand
there have been some negative comments, and I prefer not to trouble myself
with reading them - as we all have learned through our journey with this
disease, life is too short! So, I am posting this solely on the words of
those kind individuals who have written to me and told me of some of the
concerns my post generated.
Let me make something clear, my post was not to be seen as an attack on
Tracey or Zavie. I genuinely want to know who owns the list, who co owns
the list, who moderates and co-moderates, and since I personally have been
unceremoniously dumped as a co moderator, by what criteria was I dumped, and
are their rules, and if there are, what are they? I thoroughly believe in
transparency, and to that point, I hope this post makes my reasons as
transparent as possible to all of you. I will do what I can to clear up any
misunderstandings.
Furthermore, I did not make that post or this post as President of the CML
Society of Canada, but as a fellow CML patient. One, I might add who has
worked very hard over the years to provide this community with as much
credible information as possible and very often that information was
obtained at my own expense and I shared it for free. And when I say this, I
am not, NOT implying that there aren't a bunch of other people who also
contribute for which I and all of us are most grateful. I think that if we
are to continue to provide information and help here, then we should all
know what the frame work is. Once again, I would say that if we cannot be
open and honest to ourselves how can we ever hope to get the fair and equal
access to information on treatments and drugs that we all want? I hear
there has been off lists debates on my ulterior motives, a little further
down, I will share with you my views on altruism.
For now, I also want to say especially to Zavie, because apparently he asked
about it, I am delighted to tell you that there will be a new re-vamped CML
Society website launched within the next few weeks. It will have tons of
information, but it WILL NOT HAVE a CHAT LIST. So, contrary to the theory
that I am trying to solicit people to leave this list for that list, well
since there will be no list, that obviously isn't true. The issues of the
"Ask the Expert" questions will be well handled, and I am sure you will all
like the way it works out, so Zavie, thanks for your concern.
We are all human beings and as such we are fallible. I believe that
removing me as co moderator was an error, and since we are human beings and
we have the capacity to recognize our humanness, then we can forgive this
error and move on in our lives.
I wanted to mention something about altruism. I am hearing that some people
believe that it is next to impossible for anyone to be genuinely altruistic.
This has been said in the context of patients who recently traveled across
Canada to participate in a patient advisory board, and some people believe
that they did this only for the free trip and that they could not possibly
be interested in helping their fellow CMLers. The timing for this comment
in particular is interesting in that I am undertaking a specialty degree in
Bio Medical ethics and we've had a discussion on this very topic this very
week. A famous Harvard Psychologist, Lawrence Kohlberg Wrote about the
stages of Moral Development. He followed 20 people from childhood through
to adulthood and asked them moral questions and why they answered them the
way they did. He discovered there were 3 particular stages: 1.)
Pre-conventional - in early childhood, I do the right thing or else Mom and
Dad will punish me 2.) conventional - around adolescence and young adulthood
(think high school) I am only going to do the right thing if all my friends
do it too! 3.) Post Conventional, this is the highest level and it
represents growth/development. You do the right thing because you can look
at the problem from all sides and you do not fear the consequences nor your
ability to make the right moral choice and exercise good moral reasoning.
I firmly believe, that for the sake of humanity, and for the preservation of
the human race, most of us evolve to level 3 and I firmly believe that the
kind people who traveled to Montreal last weekend and took on important
tasks to help themselves and fellow CMLers to access information, treatment
and help for this disease did so and were acting at the level 3.
I also wanted to talk about the Solomon Asch study - this was a
psychological study in the late 50's - you can google it. It is quite
interesting. Anyway, the idea was that you thought you were in an
experiment with 7 other subjects, in fact, you were the only subject in the
experiment. The "subjects" were asked to look at optical illusions of lines
and tell which one out the group on the left matched the group on the right.
All other six subjects clearly chose the wrong one, then it was up to you.
37 of the 50 subjects conformed to the group's opinion, even though they
knew it could not be right. Here's something interesting to note, of those
subjects who said "no, I don't agree, I can plainly see, and trust my own
eyes, that in fact the answer should be..." all of those subjects who went
against the group had to go home afterwards as they were completely
exhausted. It takes a lot of strength and energy to speak up. I can
absolutely confirm the absolute fatigue this represents. I am asking us all
here to stop creating situations that cause many of us to stand up against
this and exhaust ourselves. We are trying to be healed from cancer and I
think creating situations that cause such harm is wrong. The only way out
of this situation is through being transparent and honest with one another.
I am not perfect either, but I am trying to be fair, honest, open and yes, I
do believe I am truly an altruistic person (acting at level 3) and I think
there are many of us on this list who are as well.
This is not the only list I belong to. As many of us do, we read several
lists, I also post and read the original ALCOR list: Subscribe to this
list-To: Listserv@..., Message: subscribe cml First name Last
Name There is no advertising, it is not for profit, and there is no spam.
Additionally there are rules, so there is a solid framework...
I also post quite frequently to Jerry's list - www.newcmldrug.com
Love and Peace,
Cheryl-Anne

re: Gleevec may be useful as an antiosteolytic agent - Richard

2008-05-23 04:33:08

Hi Tracey,
Osteoclasts (osteo=bone, clast=break, as in iconoclasts) are bone dissolving
cells, while osteoblasts (blast=grow) build new bone. What they're saying
is that at a concentration of 0.3然 (3 micromoles per cc of serum) or
higher, IM blocks the action of the osteoclasts and so may protect against
bone loss. At still higher concentrations, IM blocks the formation of
osteoclasts themselves, but it's not clear to me from the abstract what
clinical relevance this might have.
What I don't know - and couldn't find in the prescribing info for the drug -
is whether 400-800mg/day achieves a concentration of 0.3然. Do any of you
on the list know? If not, I imagine I can look it up somewhere - but it's
annoying that Novartis doesn't publish this.
I've copied the abstract below Tracey's post.
Cheers,
Richard R
PS - glossary:
antiosteolytic: anti + osteo (bone) + lytic (lysis means something like
"clastic" - it has to do with breakdown. So antiosteolytic means it stops
bone breakdown.
antiresorptive: a shortened version of anti-reabsorptive - meaning, it stops
reabsorption of bone.
Imatinib as a potential antiresorptive therapy for bone disease
Andrea L. Dewar, Amanda N. Farrugia, Mark R. Condina, L. Bik To, Timothy P.
Hughes, Barrie Vernon-Roberts, and Andrew C. W. Zannettino
From the Myeloma and Mesenchymal Research Laboratory, the Division of
Haematology, Level 2 Hanson Institute, and the Adelaide Centre for Spinal
Research, Institute of Medical and Veterinary Science (IMVS), Adelaide,
South Australia, Australia.
Osteoclasts (OCs) are large multinucleated cells derived from progenitor
cells of the monocyte-macrophage lineage. Signal transduction via the
macrophagecolony-stimulating factor (M-CSF) receptor, c-fms, is essential
for OC formation. Since we have previously demonstrated inhibition of c-fms
by imatinib, we examined the effect of imatinib on OC formation and
activity. OC formation was not affected by concentrations of 1.0 然 imatinib
and lower, but was reduced by 75% at 3.0 然 imatinib. In contrast, both the
area of resorption and the number of resorption lacunae were reduced by 80%
at 0.3 然 imatinib, and no resorption was observed at concentrations above
3.0 然. A dose-dependent decrease in receptor activator of nuclear factor B
(RANK) expression was observed in OCs when cultured in the presence of
imatinib, providing a mechanism for the decrease in OC function. In vivo
analysis of the effect of imatinib on OC activity in adult mice following 8
weeks of imatinib treatment also demonstrated a decrease in OC activity.
These results suggest that imatinib may have therapeutic value as an
antiosteolytic agent in diseases such as osteoporosis, metastatic bone
disease, and multiple myeloma.

Philipine CML group

2008-05-22 19:50:44

Hi,

Gleevec may be useful as an antiosteolytic agent - Richard

2008-05-22 19:27:45

He Everyone,
Quite some time ago I posted an abstract that showed how Gleevec
inhibited c-fms but at the time, this implication wasn't well
understood.
In the past we've seen concerns that Gleevec may negatively impact
bone development especially in those who tend to be low on phosphorus
but this article seems to indicate that Gleevec can be useful to
treat various bone diseases such as osteoporosis, metastatic bone
disease, and multiple myeloma because of the fact that it inhibits
this enzyme called c-fms.
I hope Richard will be able to "translate" this article for us so
that we can understand it better.
http://www.bloodjournal.org/cgi/content/abstract/107/11/4334?
maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=imatinib&searchid=1&
FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
Tracey
PS- In case the link doesn't work, the title of the article is
"Imatinib as a potential antiresorptive therapy for bone disease" and
I found it in Blood, 1 June 2006, Vol. 107, No. 11, pp. 4334-4337.

Re: CML patients in the Philippines

2008-05-22 12:46:19

Hi,
I'm sorry you've been diagnosed with CML but rest assured that CML is
quite a managable disease today. With all the advances in drug
treatments that we've seen over the last couple of years, you should be
able to go on living as you have most of your life.
If you're looking for others closer to where you live, your best bet
would probably be to join the Asian CML group. You can find them here:

CML patients in the Philippines

2008-05-22 02:13:55

I`ve been recently diagnosed to have CML.I would like to communicate
to other CML patients in the Philippines specially in the provinces of
Tarlac and Pampanga.

South African CML'ers

2008-05-21 18:39:21

Does anyone have an idea how I could get in touch with CML patients in South
Africa, Johannesburg (Sandton area) ?
Thanks and wishing everyone a great day,
Iris

RE: [cml 2] Finding a compatible donor for potentialtransplantation

2008-05-21 10:49:25

Hi all,
Thanks for your generous replies so far, Lea I shall write to you privately.
I didn't make myself clear on a couple of points so I shall do that now.
My husband is not able to go on the Australian and then International
Registry because he is too old. He is 50 this year and they want people
from 18 to 40 only. The age limit used to be 50 but it's now been reduced
to 40.
The point I was trying to put forward is that maybe he is too old to be on
the registry but why on earth can't he help me?
My brother would be too old to go on the registry if he had to because he is
43 this year but because he is a sibling then he can be tested.
Isn't all this rather biased?
I cannot understand why we cannot pay for a simple blood test, even for my
daughters to be tested. My eldest is 18, just old enough to go on the
registry, can't be tested for me or rather the 'red tape' won't allow her to
be tested.
Jackie

RE: [cml 2] Finding a compatible donor for potential transplantation

2008-05-21 06:13:29

I was diagnosed with CML just over a year ago and it has been a longstanding
issue of finding a transplantation donor. I have absolutely no intention of
going down that avenue unless I had to but would like the reassurance of
knowing that I do have a compatible donor out there somewhere!
My brother who lives abroad has messed me around for the past 8 months about
taking the blood test to see if we are compatible and I am still no further
forward to finding a donor, if I should ever need one!
I live in Geelong, near Melbourne, Australia. My husband has repeatedly
tried to get a blood test to see if he is compatible, to be told that he has
to register to help others as well. He doesn't want to do this but wants to
help me and is not able to. He is not even able to physically pay privately
for a blood test to see if he is compatible.
My ex-husband who also volunteered to be tested has been told that he does
not qualify to be a blood donor in this country. He is an Australian
Citizen and moved here from UK in 1999.
My oncologist told me that there is 'no point' in my daughter being tested
as the statistics say that there's a 99% probability that she won't be
compatible.
Blow to statistics! MY point of the matter is that the system sucks! How
on EARTH can I obtain a donor match if the system won't let anyone be tested
for compatibility??? Can someone please explain my dilemma?
Jackie Petropoulos,
Geelong, Australia

Re: [cml 2] An IRISH Blessing

2008-05-21 03:12:58

OK:
Why don't you just let this go? This venue is not the place or time to carry on
with personal vents. Speaking for myself, I am tired of your BS. Lets get back
to interaction about CML to help people not make this siteabout your personal
feelings being justified.
Cheryl-Anne Simoneau <cheryl.simoneau@...
Hello All,
Here's something to think about:
May those who love us love us.
And those that don't love us,
May God turn their hearts.
And if He doesn't turn their hearts,
May he turn their ankles,
So we'll know them by their limping.
So, for those folks who felt it necessary to write hurtful angry messages, I
guess we can say that their ankles have been turned and now we know who they
are and this being a support group we can send loving kindness and prayers
and meditations to these people so that they will overcome their anger and
work on their own healing. Maybe with time we will be able to reach out to
these people and help them in their journey towards love and acceptance.
Peace, Love and all groovy things,
Cheryl-Anne

Re: [cml 2] Digest Number 614

2008-05-20 16:15:04

Hey Group:
After being diagnosed and given only 2-5 months to live; I was steered to the
group by a brother survivor. At that time there was 'discord'; Amy having the
foresight, began this group. I was glad she did, because I received all the
information and support I needed from the Pioneers at CML2. Thanx again Amy.
Cheryl, I'm sure you remember what transpired during that time and we
definitely don't need a repeat. Being a Newbie then, I know what I was thinking
as I'm sure they are at this time.
The only good thing that came out of it was Amy's beginning this group; which
afforded me 4 CML Groups in which to access for information and support.
This is 2007 and you have began your own CML Society and as we all know. .
.you are a very busy woman. Therefore, your time and energy is best spent in
getting your site up and off the ground, not in trying to disband this site.
I was elated that I had 4 Groups in which to access the Information and
Support I so desperately needed. These Newbies should have the CML2 group and
your CMLSociety of Canada group in which to access for information and support
from the Pioneers as I did in 2004.
Thanx Pioneer Brothers & Sisters for being there for me through the CML2 Group
and PLEASE continue to be here for us; because we do need your expertise.
Take care. . .I have ALL my Brother & Sister Survivors in my prayers.
"K"
"I AIN'T FINISHED YET"!!!

An IRISH Blessing

2008-05-20 10:45:09

Hello All,
Here's something to think about:
May those who love us love us.
And those that don't love us,
May God turn their hearts.
And if He doesn't turn their hearts,
May he turn their ankles,
So we'll know them by their limping.
So, for those folks who felt it necessary to write hurtful angry messages, I
guess we can say that their ankles have been turned and now we know who they
are and this being a support group we can send loving kindness and prayers
and meditations to these people so that they will overcome their anger and
work on their own healing. Maybe with time we will be able to reach out to
these people and help them in their journey towards love and acceptance.
Peace, Love and all groovy things,
Cheryl-Anne

Re: [cml 2] Thanks for the kindness and generosity

2008-05-20 10:33:59

Hi Cheryl-Anne,
Let me add my support. You've worked very hard for all the years I've been on
our various lists. When no on e else answered a question, you would do some
research and reach out to that person. Thanks for everything. As we all try to
get a grip on the meaning of various symptoms, lab results, cold docs and ways
to deal with oddball side effects you've always been there slugging away with
us.
Best regards and groovy things to you, too.
Susan Loewenkamp

Thanks for the kindness and generosity

2008-05-20 04:50:33

Hello Folks,
Just a few public words of praise to the very kind people who have sent me
encouraging words. Reading my emails in my inbox this morning was quite a
pleasure and a treat. There are so many warm and kind individuals amongst
us, and I am so thrilled that you have shared your warmth and kind words
with me. In fact, the warmth and kind words required two cups of skinny
cafe au lait and I haven't finished reading them all. What a wonderful
lovely day this will be!
Thanks for reaching out, your very kind words are all very well appreciated.
Peace, Love and all groovy things,
Cheryl-Anne
"Imagine there's no countries, It isn't hard to do
Nothing to kill or die for, And no religion too
Imagine all the people, Living life in peace... "
John Lennon - Imagine

A powerful thought

2008-05-20 01:54:16

Harboring resentment is like taking poison and hoping it will hurt the other
person. There is a temporary feeling of power with thoughts of resentment
but this is short-lived, feeding the egos desire to be superior and
righteous. Slowly this poison takes over and will infect my whole inner
world unless I stop it. Today let me transform resentment into the sweet
nectar of kindness and peace and eliminate the poison of resentment from my
system.

Moderators

2008-05-19 21:30:26

Cheryl-Anne,
But I still love ya!
Bob Stewart, Granger, Indiana

Re: [cml 2] Dasatinib user for 2 years and feeling fine!

2008-05-19 15:49:42

Hi Kimberly,
My best friend's daughter was named Sage......love that name, she is in her
30's now. I remember old posts from you. As far as a dose of
150mg......most people in the trial are on 140mg (two 70mg pills) or 100mg
(two 50mg pills). So the 150mg dose is really not that much higher. I do
remember one teenager who went into a trial and his dose was higher than
140mg. There is a concentration of people on dasatinib posting on Jerry
site (www.newcmldrug.com) on his Sprycel Talk list.
Sounds like Michael is doing great. I have been on Sprycel (100mg) for just
over a year and I also feel better than I did on 800mg Gleevec.
Best to you and your family.
Nancy C.

RE: [cml 2] This List

2008-05-18 23:15:42

Cheryl-Ann,
As the president of the CML Society, I find your post unconscionable. It
appears to be an attempt to destroy the CML2 list.
Perhaps you can better spend your time by answering the questions on the
"Ask the Experts" part of the CML Society website. It has been one year
since any of them have been answered.
Zavie
Zavie Miller (age 68)
67 Shoreham Avenue
Ottawa, Canada, dxd AUG/99
INF OCT/99 to FEB/00, CHF
No meds FEB/00 to JAN/01
Gleevec since MAR/27/01 (400 mg)
CCR SEP/01. #102 in Zero Club
PCRU 5/02 at RVH
2.8 log reduction Sep/05
3.0 log reduction Jan/06
e-mail: zmiller@...
Tel: 613-726-1117
Fax: 309-296-0807
Cell: 613-202-0204

Re: This List

2008-05-18 21:16:40

Dear Cheryl Anne,
I feel that this post of yours is a very bad lapse of judgement on
your part. If you have "private" conversation via email, why are
you airing the conversation for the entire CML2 community to hear?
This is one of those times where you should have maybe written down
your feelings and frustations, printed it, and then burned it in the
fireplace. This support group is not the appropriate place for you
to air your issues with others.
Isn't it enough that you battle CML, work full time, and run CML
Society in Canada? Have you ever considered that maybe you have a
deep seeded need for control? Maybe there is help out there for
you, but this is not the place.
We all come to this support group site for knowledge, comfort, and
bonding with others who share our same disease. I have always
appreciated anyone who takes the time and energy to help a fellow
CML'er or caregiver in need. But, I feel that this particular post
of your really crosses over the line.
Just my thoughts, Lynn
PS: I am not a moderator, co-moderator, nor ever wish to be one.

Dasatinib user for 2 years and feeling fine!

2008-05-18 15:41:34

Happy New Year, Everyone:
I just rejoined this site after 3 years off, due to the birth of our
2nd daughter, Sage.
My husband, Michael, was diagnosed with CML in 1998 at the age of
38. While at MD Anderson, he tried both Interferon [horrible side
effects, no remission], and Gleevec - 800 mg daily [4 years,
fluctuating remission, virtually no side effects and finally
relapsed completely] both to no avail.
In the summer of 2005, he joined the BMS trial at MD Anderson and
this finally did the trick. He's been in full cytogenetic remission
for the last 1 and 1/2 year and he has no little to no side effects
at all.
He works full time, goes to the gym and is a busy father to our 2
small daughters. He takes 150 mg daily of the dasatinib.
I'm curious to know if there's anyone out there who also takes such
a high dose of the dasatinib and if so, how you're doing.
Best wishes to everyone and God bless,
Kimberly Pendergrast Harris
Silver Spring, Maryland

This List

2008-05-18 09:50:00

Dear All,
Last week there were a few events that transpired "off list" which
may have percipitated my being removed as a co-moderator of this
list. In an effort ot be fair an open, I wish to explain the
following.
When Amy started this list about two years ago, I volunteered to be a
co-moderator and lend whatever support I could in helping this list
prosper after the breakdown of the original list.
However, last week, without provocation by me, Tracey has decided to
remove me as co-moderator. When I asked Tracey why she felt it
necessary to remove me from the list, she said she had discussed this
with other co-moderators of the list, whom she refuses to name, and
with the list owner Amy, and that by some criteria, which she will
not tell me about, the decision was made to remove me as co-
moderator.
Why bother airing this on the list? Will this post even make it to
the list? The point is that this is unacceptable behavior. In a
private e-mail with the list owner, Amy, Amy herself told me that she
was not involved in the decision and she was not even made aware of
it. It seems now that it was an arbitrary decision and not at all
handled in a fair and judicious manner. How can anyone who try's to
step up and be a leader here, cause friction against other members
and "stir up the pot" to use their own words. You would think that a
person who takes leadership would be fair, transparent and democratic
in their approach.
In private communications with Tracey and Amy I have asked that we
know who the co-moderators of this list are and who are the co-
owners. Yet Tracey has said we do not need to know. In saying this
she is saying in fact that she does not believe that we CMLers who
share our information and participate in making this a viable list
are entitled to know who judges who can participate in this list or
who cannot and by what criteria are those decisions being made.
This is completely unacceptable. Furthermore, Tracey has e-mailed
and spoken directly to people in an effort to undermine my
willingness to help this community and has said quite negative things
about me. None of which she would even know first hand as she has
never met me. Other than a couple of e-mails this past weekend,
Tracey and I have not communicated. So how she obtains this
information about me is quite mysterious to me to say the least.
Why should any of us be part of this list where the co-owner insights
such animosity amongst its fellow leaders.
There are other lists, who are led by people who have integrity and
respect the rights of all fellow patients to access and contribute to
information and resources for fellow CMLers. The other lists have
clear rules, do not instigate hatred and provide fair and transparent
leadership. We know the criteria and the rules and the moderators.
These very good qualities that I have pointed out and they are
seriously disregarded here.
I believed in this list and the reasons it was started a couple of
years ago. I really like the majority of the people I have met
here. But I cannot condone such poor behavior. I would strongly urge
everyone of you to find your resources and help elsewhere in a more
warm and friendly environment.
In the end, I am a very busy person and I do not have time for
childish games. But you all deserve to know that the very thing
those of us tried to stop by supporting the creation of this list has
once again happened. Once again, we are not to know who co-moderates
this list, nor the criteria used to moderate this list.
Love and Peace,
Cheryl-Anne
cheryl.simoneau@...

[cml 2] AMN-107-Skip

2008-05-18 05:00:12

Skip,
Just curious--what kind of treatment do you receive twice a week for
your low counts?
Cam

This email has been scanned by Barracuda Network's Anti-Virus and Spam Firewall.

Re: [cml 2] headache:

2008-05-17 21:13:05

Yes, quite a few people experience headache when they start Sprycel....but
usually it does not last real long (few days to a few weeks). People take
whatever strength of medication that they need, so ask your doctor.
Nancy C.

Re: [cml 2] AMN-107-Skip

2008-05-17 17:03:33

In a message dated 1/25/2007 9:10:27 P.M. Eastern Standard Time,
skipd_2002@... writes:
have been on AMN107 for about 2 months, it is too
early to tell. In my case that is. My Doctor is
hopeful I feel good and according to others look good
but I am receiving treatment for low counts twice week
Dear Skip, thanks for stepping up and telling us about AMN. I am very
interested in going on this drug. How did you get it? Where are you treated
and
are you on trial? - Lynne A.

Re: watery eyes and spironolactone

2008-05-17 13:04:25

Taking spironolactone (Aldactone) without having high blood pressure is usually
no
problem, since it's a fairly weak diuretic and not likely to drop your BP too
far. If it did,
you would know it because you'd feel lightheaded when you stand up. If this
doesn't
happen (and assuming you have good kidneys - a separate issue), you should be
fine. Let
us know if it helps with the bags under the eyes!
Richard R

Chat Reminder - Saturday 9:00 AM - Skating on the Rideau Canal

2008-05-17 08:35:02

Chat Reminder - Saturday 9:00 AM
Photo - The Canal opened for skating yesterday

a person need bon marrow who can help hime

2008-05-16 19:46:21

hi i am hassan. i have cml since 1999. i am taking glivec now. so a person in
usa need help for bms and bon marrow his name is nima and he is 19 years old and
he has ALL
for mor info please look his web sit:
www.helpsavenima.com
thank you

Re: [cml 2] watery eyes and spironolactone

2008-05-16 10:06:22

When I was on Gleevec (I am on Sprycel now) Dr. Druker Rx'd me with
a diuretic (diazide) that is also a blood pressure medication. When I asked
him about that....he said, to lower blood pressure you get rid of water.....
he used this one because it spares potassium also.
Nancy C.

Re: [cml 2] Slow Responder/Vicki

2008-05-16 09:46:03

Hi Vicki,
Many of us have moved on from our initial hem/oncs.......your's may be
fine, but this is about us and our CML and not about them. My present local
onc is in awe of Dr. Druker and always says "I hear he might get a Nobel
prize"......he would never question what Dr. D wants whereas a previous onc
always challenged what he said (so I fired him).
Eugene is a great town....and also has lots of alternative/complementary
medicine. Also, when you are an OHSU patient, you have good access to their
oncology pharmacist to ask about drug interaction, etc. Many people, even
doing very well, have seen Dr. D just for peace of mind! it is worth the
price.
Best to you,
Nancy C.

Re: [cml 2] AMN-107

2008-05-16 02:07:35

I have been on AMN107 for about 2 months, it is too
early to tell. In my case that is. My Doctor is
hopeful I feel good and according to others look good
but I am receiving treatment for low counts twice week
Skip

watery eyes and spironolactone

2008-05-16 01:38:12

hi everyone,
just have a few questions about spironolactone{dieretic}. Last
time I was at the docs. office he gave me this drug for my water
retention,especially around the eyes.He said it will not deplete my
potassiom like a reg. dieretic. I was reading the imformation sheet
that came with it and this medication is used to also treat high blood
pressure. I do not have high blood pressure should i be taking this
medicine. I also have been having trouble putting my contacts in
since my eyes are so watery, has any one had this problem,and has
anyone had laser surgery on your eyes since being dx.with leukemia and
have been on gleevec dx Oct.06

Re: taking gleevec

2008-05-15 19:42:32

I take Gleevec at night an hour before bedtime. So I go to sleep
and wake up fresh and energy. I notice I sleep longer (9hours).
Normally I sleep 7-8 hours before I started Gleevec. A trouble
taking Gleevec at night is getting up to pass water in the middle of
the night. I drink 12 oz of water when I take Gleevec. I try to
take it earlier than an hour before bed.
Siu

AMN-107

2008-05-15 09:42:25

Hello all,
What about AMN-107? Noone talks about it, does it work or not? Anyone here
using it? I see its not as popular as Sprycel, why?
Thanks..
Yusuf Cipe
Istanbul

Re: Slow Responder

2008-05-15 06:26:50

My counts plummeted after starting Gleevec. I was on 300mg of
Allopurinol (anti Gout) weeks before even starting Gleevec and was
just about crippled from gout. The gout stuck around for over a month!!!
Now, I'm having issues with keeping my counts from being too low. I
had to take a week off just to get my neutrophils up to a respectable
level. I've been concerned that Gleevec isn't going to work for me
because it seems to be too strong. My Onc thinks my good cells just
need to catch up with the displacement of the leukemic cells.
James
dx 7/13 with 196WBC

Re: [cml 2] taking gleevec

2008-05-15 01:06:24

My husband takes it about 15 minutes before bed...he has a bowl of
cereal and takes it, then crashes within 30 min. That way most of the
side effects aregone by morning..
shalyn

taking gleevec

2008-05-14 19:51:32

I HAVE A QUESTION ABOUT WHAT TIME PEOPLE TAKE GLEEVEC.MYSELF I TAKE IT AT LUNCH
AS THAT IS MY BIGGEST MEAL.DEPENDENG ON WHAT I EAT DEPENDS HOW MUCH SIDE
AFFECTS.I JUST GOT MY CHOLESTEROL REPORT SEEMS I HAVE TO EAT BETTER.I ALSO FINE
DRIVING IS BETTER AS I HAVE WET EYES AND MAKES FOR BLURRY VISION
PAUL TN DXT 12/O6
-----

Re: [cml 2] new medicine/Matt

2008-05-14 13:59:04

HI Matt,
Yes, I think the Neti Pot came from Yoga. Some people just 'suck' saline in
through the nostril and then let it come out the other side.....the Neti
Pot makes it easier, you literally pour the saline in one nostril and it
comes out the other (over the sink of course!). The warm saline water is
very soothing to dry nasal passages and also flushes stuff out.
I used to work at a Uni student health center.......and the RNs there would
teach this to all the students with sinus infections, etc. They actually
taught them to have a small cup of saline, suck it up a nostril, tip your
head back to get into the sinuses.....then bend forward and let it run out.
It is easier than it might sound.
My first 5 months on Sprycel were rough for me (lots of body aches,
congestion, etc).......now I have hardly anything that I notice. Many
people on Sprycel feel better than they did on Gleevec. Actually, Dr.
Druker (my onc) told me that he expected anyone on 800mg of Gleevec (me) to
feel better on Sprycel. Now I am waiting for some pcr results from my last
visit.
Nancy C.

Re: [cml 2] Slow Responder

2008-05-14 02:43:27

Vicki:
I am sure you will hear different opinions on this. My oncologist at MD
Anderson is one that feels that you should be on higher doses, as certain
reports show that a quicker response shows better long term results. But there
are
people on this site who have been a minimal doses, responded more slowly and
are doing very well. So I am not sure that the "higher is better" school of
thought is best.
I will say that I have been on doses as high as 800 mg and the side effects
are more prevelant and your QOL diminished, if you experience the side
effects. I prefer life on the lower doses much better than I did on the higher
doses.
My best regards,
Matt
Florida
In a message dated 1/24/2007 1:39:31 PM Eastern Standard Time,
vickistu@... writes:
My heme/Onc has told me I am a "slow responder" to Gleevec, but not
to worry--it is working. I am wondering if I need to be on a higher
dose or what? I don't like the slowness of the response--it worries
me that somehow I am resistant to the good effects of the drug.
I was diagnosed 10/04/06 and have been taking 400 mg of Gleevec since
that date. My counts are gradually drifting downward, sometimes
upward, then back down again--and I am still not at normal wbc counts
(that is mainly what I watch). Does anybody else have experience
like this? Should I ask to be on a higher dose? My doc says that
even if it takes 4 years to get to normal counts--people who take
that long do just as well long-term as people who respond quickly. I
have not read enough to know if that is true, and thought I'd ask
around this group to see if anybody knows if that is the case?
I don't want to develop a resistance to the Gleevec, and if taking it
at higher doses would make it work better and faster, and if over the
long run that is a good thing, then I want to do that. Also, what
about clinical trials? I am seeing a doctor in a smaller suburban
heme-onc practice. Should I go for the big downtown practice which
has the clinical trials or stay where I am care-wise? It is very
much a dilemma for me since I love my doctor and she seems quite
knowledgeable, although she admitted to me that she only had 5 CML
patients, and I am one of the 5.
Thanks for your input. It really helps to hear somebody's opinion
who has been through similar things. I am battling lots of side
effects and depression, and members of the group have helped me
tremendously in terms of seeing that this disease is more manageable
than I had dreamed, and truly not an "end of life" kind of
situation. How magnificent a gift that was and is every single day!
Thank you so much to all.
Vicki

Slow Responder

2008-05-13 21:59:14

My heme/Onc has told me I am a "slow responder" to Gleevec, but not
to worry--it is working. I am wondering if I need to be on a higher
dose or what? I don't like the slowness of the response--it worries
me that somehow I am resistant to the good effects of the drug.
I was diagnosed 10/04/06 and have been taking 400 mg of Gleevec since
that date. My counts are gradually drifting downward, sometimes
upward, then back down again--and I am still not at normal wbc counts
(that is mainly what I watch). Does anybody else have experience
like this? Should I ask to be on a higher dose? My doc says that
even if it takes 4 years to get to normal counts--people who take
that long do just as well long-term as people who respond quickly. I
have not read enough to know if that is true, and thought I'd ask
around this group to see if anybody knows if that is the case?
I don't want to develop a resistance to the Gleevec, and if taking it
at higher doses would make it work better and faster, and if over the
long run that is a good thing, then I want to do that. Also, what
about clinical trials? I am seeing a doctor in a smaller suburban
heme-onc practice. Should I go for the big downtown practice which
has the clinical trials or stay where I am care-wise? It is very
much a dilemma for me since I love my doctor and she seems quite
knowledgeable, although she admitted to me that she only had 5 CML
patients, and I am one of the 5.
Thanks for your input. It really helps to hear somebody's opinion
who has been through similar things. I am battling lots of side
effects and depression, and members of the group have helped me
tremendously in terms of seeing that this disease is more manageable
than I had dreamed, and truly not an "end of life" kind of
situation. How magnificent a gift that was and is every single day!
Thank you so much to all.
Vicki

Re: [cml 2] new medicine

2008-05-13 17:53:22

Hey dantelb:
I started Sprycel in December 06. Yeah the headaches were bad but that side
effect wore off quickly. I no longer have headaches with Sprycel. It seems
like a drug with lesser side effects than Gleevec.
The only problem I have concerns my stomach. I have been on Protonix for years
and had to stop because it interferes with Sprycel effectiveness. Tums and
Malox don't help me that much. It is nice not to have the severe cramping
anymore that Gleevec caused. Let me know your experience. Hope it goes well.
Therese
dantelb <dantelb@...
Everyone I been takeing Gleevec for the pass 3yrs now for my
CML.. and now my doctor switch to a new medication Called Sprycel..
Have you heard of sprycel be4 if you do please tell me, cuz im have
headaches everyday.. thanks

Re: new medicine

2008-05-13 11:41:40

Hi,
Welcome to the group.
Yes we have heard of Sprycel. Some members of the group are taking it
but there is another board that is dedicated to topics of Sprycel.
You can check it out here:
http://www.newcmldrug.com/bms_discuss/default.asp
I can tell you that many people have reported having headaches on
Sprycel but the headaches do eventually stop. Sometimes it can take
a couple of weeks though.
Tracey

CML doctor referral continued

2008-05-13 00:13:30

I got 3 names from my preferred PCP, 2 are in the same practice:
Dr. Andrew J. Wagner, 541 Main St, Ste 414, Weymouth MA.
Dr. Rolf Freter, 541 Main St, Weymouth MA.
Dr. Barry Miller, 700 Congress St, Ste. 102, Quincy Ma.
If anyone has heard of any of them please let me know.
Thank you,
Alicia

new medicine

2008-05-12 22:41:37

Hello Everyone I been takeing Gleevec for the pass 3yrs now for my
CML.. and now my doctor switch to a new medication Called Sprycel..
Have you heard of sprycel be4 if you do please tell me, cuz im have
headaches everyday.. thanks

IM serum level testing - Cam, Lynn

2008-05-12 10:37:51

Hi Cam and Lynn,
According to Dr. Druker, per the exchange below, Merrill Egorin at U. of
Pittsburgh is willing to run IM levels on the serum of patients other than
his own. You might want to pass along this info to your docs and ask them
send a sample of yours for testing.
Richard R

Doctor recommendation in Southeastern MA, USA

2008-05-12 10:20:36

Hey guys,
I've been driving into Boston each month for my checkup for over a year now. I
would like to find a local doctor so that I can go back to using my local
primary care physician. I plan on calling my preferred PCP today to get names
from her but I was wondering if anyone had any suggestions of good CML doctors
in the Braintree, Weymouth, Quincy, Hanover, Hingham, Randolph area of Mass.
Please let me know if you know of anyone.
Thank you for your information,
Alicia

Re: Richard R. and serum levels Lynn and Richard R.

2008-05-12 07:36:11

Hi All,
The only information I have is what Novartis announced at their booth
at ASH. The Program is called CML Alliance and from what I
understand Novartis is endevouring to build a strategic alliance with
a CLIA-Certified Laboratory with significant expertise in blood level
testing. This is a voluntary program and will be offered to patients
experiencing a sub optimal response to Gleevec.
In the informaiton we have received we do not know what "sub optimal"
response means or how it is defined. I am not sure what body of
evidence will be used to make that assessment. I say this only
because there was some discussion at ASH on what defines an "optimal"
response to Gleevec. I asked the question yesterday to Dr. Pierre
Laneuville and Dr. Jeff Lipton from the perspective of a patient who
is having a good response yet suffering difficult side effects, and
while those patients may be offered testing, the first priority is
patients with a sub optimal response. Since this could be a costly
program there will have to be some criteia established on who and
when patients can be offered testing.
However, I am in touch with Novartis and I will be happy tokeep
everyone updated with more information as it becomes available.
Hope some of this helps,
Cheers,
Cheryl-Anne

Re: [cml 2] Nashville doctor's test taking guesswork out of chemo - Nashville...

2008-05-12 02:44:19

Hello,
I hope you don't mind, but the link wouldn't work. I just searched it and
sent a corrected one for the loop.
_Nashville doctor's test taking guesswork out of chemo - Nashville,
Tennessee - Monday, 01/22/07 - Tennessean.com_
(http://www.tennessean.com/apps/pbcs.dll/article?AID=2007701220355)
I live near Nashville and my doctor is based at Vanderbilt University
Hospital. His name is Dr, Richard Stein and I can't say enough about him or the
hospital. He actually told me about this study last Aug. I was dx in May so I
was still new to CML and didn't really understand it all at the time. It is
wonderful to think that one day we will just have to have a simple blood test
and be put on the correct med from the start.
C.Weeks
dx May 2006
WLS May 2005
In a message dated 1/22/2007 5:39:41 A.M. Pacific Standard Time,
zmiller@... writes:
_http://www.tennessehttp://www.thttp://wwhttp://www.thttp://wwwhttp://www.htt_
(http://www.tennessean.com/apps/pbcs.dll/article?AID=/20070122/FEATURES04/701)
220355
Very interesting. Could a similar approach be used for CML?
Zavie
Zavie Miller (age 68)
67 Shoreham Avenue
Ottawa, Canada, dxd AUG/99
INF OCT/99 to FEB/00, CHF
No meds FEB/00 to JAN/01
Gleevec since MAR/27/01 (400 mg)
CCR SEP/01. #102 in Zero Club
PCRU 5/02 at RVH
2.8 log reduction Sep/05
3.0 log reduction Jan/06
e-mail: _zmiller@..._ (mailto:zmiller@...)
Tel: 613-726-1117
Fax: 309-296-0807
Cell: 613-202-0204

Nashville doctor's test taking guesswork out of chemo - Nashville, Tennessee - Monday, 01/22/07

2008-05-11 19:31:14

http://www.tennessean.com/apps/pbcs.dll/article?AID=/20070122/FEATURES04/701
220355
Very interesting. Could a similar approach be used for CML?
Zavie
Zavie Miller (age 68)
67 Shoreham Avenue
Ottawa, Canada, dxd AUG/99
INF OCT/99 to FEB/00, CHF
No meds FEB/00 to JAN/01
Gleevec since MAR/27/01 (400 mg)
CCR SEP/01. #102 in Zero Club
PCRU 5/02 at RVH
2.8 log reduction Sep/05
3.0 log reduction Jan/06
e-mail: zmiller@...
Tel: 613-726-1117
Fax: 309-296-0807
Cell: 613-202-0204

Testing Photos

2008-05-11 08:35:33

Zavie Miller (age 68)
67 Shoreham Avenue
Ottawa, Canada, dxd AUG/99
INF OCT/99 to FEB/00, CHF
No meds FEB/00 to JAN/01
Gleevec since MAR/27/01 (400 mg)
CCR SEP/01. #102 in Zero Club
PCRU 5/02 at RVH
2.8 log reduction Sep/05
3.0 log reduction Jan/06
e-mail: zmiller@...
Tel: 613-726-1117
Fax: 309-296-0807
Cell: 613-202-0204

re: Richard R. and serum levels

2008-05-11 07:35:09

Hi Lynn,
No, I don't know who's able to do levels, but I should find this out.
Cheryl, do you know? I'll email Dr. Druker and see what he knows.
All the best,
Richard R

Chat Reminder - Saturday 10:00 AM

2008-05-10 16:12:54

Chat Reminder - Saturday 10:00 AM
Photo: NGC - National Gallery of Canada Ottawa, Canada

Richard R. and serum levels

2008-05-10 15:17:28

Hi Richard,
Do you have any idea what Cancer Centers are doing standard serum
level testing in the US now? Are certain nationwide labs being
taught how to conduct the test yet?
It sure would be nice to have every CML patient do a study to
compare PCR results vs dosage and serum level.
I have always felt that for my body, 400 mg was too much, and I
suffer the side effects as well. I'm PCRU but I am sick most of my
days. (In a nutshell!) I'm a stay at home Mom. I don't work
because my days are so unpredictable with the side effects. Up and
down like a rollercoaster! I also don't get Disability because I
was diagnosed while raising children and not working. Isn't our
system great?
I have young children, and don't want to risk my PCR status messing
with lowering my dose, until I see the serum level test results.
When you find out any more about this, can you please let our group
know?
It would be very much appreciated! Many thanks for all you do!
Lynn

Digest 605

2008-05-10 15:14:51

Hey Group:
I had to quit smoking Marijuana years ago when the children became old enough
to know because kids were calling the police on their parents (hehehe). I don't
think anyone will take the Marinol pill form who has ever smoked (hehe).
Margot. . .CONGRATS! ! ! RAH**RAH**RAH! ! ! Zavie & U I will be able to add to
my 'updated' letter for the Newbies; which is in the rough draft stage now. I
remember 3-5 years being survival--a lot longer than the 2-5 months I was given.
We've come a LONG way and the newly diagnosed, I believe will virtually have
normal life spans. I am in my 4th year now, and I'd told Zavie that I didn't
think I would reach PCRU. . .but who knows? At 0.00136 I may be well on my way
right now and not know it. As Tracey posted, YOU are an Inspiration to us all, &
one of my 'special' sister survivors. As for side effects and my Chronic
Illnesses; I ignore ALL in my survival and say 'I AM FANTASTIC' when asked by
anyone. Margot also an 'early' CONGRATS~~9 years~~FANTASTIC ! ! ! (I shed a
'happy tear').
Cora for Cam, my H/O office gave Procrit to me in 2004; and if my 'gold' brain
serves me correctly. The insurance wouldn't pay for me to have the Neupogen at
home; but he could give me the Procrit shots in his office. Just a thought, the
Neupogen may cost quite a bit more than Procrit.
Take care all. . .in my prayers. . ."K"

Re: Please Read,

2008-05-10 04:03:59

Hi Andrea,
My name is Lynn, and I was diagnosed with CML a month after you in
December, 2003. I am now 44.
You know what? My first Hem/Onc really pushed me for transplant
too. Although I was doing fabulously on Gleevec, he was very old
school, and didn't believe that Gleevec could give me durable, long
term results.
I had my siblings tested, and neither were acceptable matches. I
also had a consult at the Fred Hutchinson Center, in Seattle, near
where I live. They gave me the pro's and cons of the procedure, and
later, after returning, I wrote a huge list of pros vs. cons on a
piece of paper. It not only had to do with health, but insurance,
living arrangments, spouse, children, caretakers, pets and lots and
lots of money. For myself, the cons ran off the page.
When you go to a transplant center, they are going to push for what
they do, transplants. Plain and simple, they are a business first.
My first Hem/Onc and I really had it out one day, when I told him I
was making a choice NOT to have a tranpslant. He demanded that I
do, and when I flat out refused, he yelled at me and reamed me and
put me to tears. He refused to look at any data that I had gathered
about mortality rates of transplant vs Gleevec! I walked out of his
office, and when he said, "Where are you going?" I said, "I'm
leaving and I'm FIRING YOU!".. 3 months later, he retired!
If you haven't spoken and had a consultation with a notable CML
specialist, I would suggest you start there.
I realize you are quite young to be diagnosed with such a sucky long
term disease, like CML, but you have many choices available to you.
Think long and hard.
Hopefully, you will get much more input from the others on this
list.
Sincerely and best wishes,
Lynn (Snickersunny)
Dx'd 12/03
PCRU

Please Read,

2008-05-09 21:48:44

Hello my name is Andrea, I don't post often but I read everyone's
post. I am 25 years old and I was diagnosed with CML in November
2003. I have been taking Gleevec 400mg since the day I was diagnosed.
Not to many side affects bone pain in the beginning but that went away
after about 2 years. I get a little sick sometimes after taking
Gleevec but nothing to major. My PCR has been good since January 2006,
and continue to look good. I went in for my 4 month appt. and my
doctor is pushing me to talk to the transplant specialist in case the
Gleevec stops working. They have already called me back today to set
up an appt. to talk about the procedures of transplant and to get my
siblings testes. I am very scared and confused and not sure what to
do. I would to hear your comments.
Andrea
DX 2003, at the age of 22

Re: [cml 2] Please Read,

2008-05-09 20:28:47

Andrea:
That's seems a little unusual, because if the Gleevec loses it efficacy,
there are other drugs including
Sprycel, that are alternatives to Gleevec. In fact, Sprycel is considered
much more powerful than Gleevec. You probably know this already.
However, I was asked early in my treatment to go to a BMT center and be
tested, which I did. It was found that my brother is a donor match and if
needed, I could have a BMT. The transplant doctor did not recommend a BMT, in
fact
she counseled me against it. She said that Gleevec was the front line
therapy and that I should stay on that as long as I can.
If he is only doing it for testing purposes, then you may at least determine
your options. However, I would be very careful in considering a BMT,
especially since you have responded to Gleevec.
With warm regards,
Matt
Jacksonville, FL
DX January of 2005
Gleevec Since May 2005
Father of 3
mtmaynor@...
In a message dated 1/19/2007 5:13:52 P.M. Eastern Standard Time,
formiga101@... writes:
Hello my name is Andrea, I don't post often but I read everyone's
post. I am 25 years old and I was diagnosed with CML in November
2003. I have been taking Gleevec 400mg since the day I was diagnosed.
Not to many side affects bone pain in the beginning but that went away
after about 2 years. I get a little sick sometimes after taking
Gleevec but nothing to major. My PCR has been good since January 2006,
and continue to look good. I went in for my 4 month appt. and my
doctor is pushing me to talk to the transplant specialist in case the
Gleevec stops working. They have already called me back today to set
up an appt. to talk about the procedures of transplant and to get my
siblings testes. I am very scared and confused and not sure what to
do. I would to hear your comments.
Andrea
DX 2003, at the age of 22

Post ASH - Sunday January 21, 2007 Montreal

2008-05-09 09:33:24

Hello All,
I am delighted to say that there are quite a few of us getting together this
Sunday, January 21, 2007 here in Montreal for our Post ASH meeting.
Below is the agenda, with the address and telephone of the hotel. I would
suggest you call for directions if you are not sure. It is a brand new
hotel and does not show up on Map Quest.
You can reach me at the CML Society on Saturday afternoon at 514-932-7575 or
our toll free number 1-866-912-7575. I will be happy to help with
directions.
If you have not already confirmed your presence, please do so today as we
need to arrange for the right amount of refreshments for our fellow CML
patients.
Looking forward to seeing you all on Sunday, January 21, 2007 at 1:00 PM
Cheers,
THE CML Society Post ASH Meeting
DRAFT AGENDA
Sunday, January 21, 2007
Marriott Hotel
7000, Place Robert-Joncas, Saint-Laurent (Montr嶧l, Qc) T: 514-339-5333
(On the north side of the TransCanada service road going west)
This is a new hotel and is not listed on Map Quest
13h00 ASH debrief Welcome
13h15 Introduction of the CML Society, preview of the Website
and first Newsletter
Upcoming activities of the CML Society Cheryl-Anne Simoneau, President
13h20 Quick update on the Follow up of the French Study from
this years ASH Cheryl-Anne Simoneau
13h25 Physician perspective: Dr. Jeffrey Lipton, IRIS update and
Start R trial
13h50 Physician perspective: Dr. Pierre Laneuville: Rationale for
blood serum level testing, drug transporters and drug metabolism
14h25 Questions
14h30 End of meeting
Please stay for chatting, coffee and cookies - CCC

Re: Low dose of IM - Cam &amp; Richard

2008-05-09 08:05:33

Hello Cam,
Just a little note to let you know that I agree with everything that
Ricahrd has posted here in this case. As you will be joining us on
Sunday, you will hear Pierre Laneuville talk about Blood Serum level
testing, Drug transporters and the various issues that provide the
rationale for differing the doses like Richard pointed out here.
By the way, when I used to cycle on Gleevec, my kidneys tolerated it
much better.
Looking forward to meeting you this weekend and having more
discussions on this.
Cheers,
Cheryl-Anne

Re: Nice blood counts reference.

2008-05-09 00:11:44

Found this link to be very useful as well for understanding causes of
low blood counts and more interestingly, nutrition to improve counts.
Shark liver oil???
http://www.lef.org/protocols/heart_circulatory/blood_disorders_02.htm

Nice blood counts reference.

2008-05-08 13:18:11

Thought I would share.
http://patient.cancerconsultants.com/supportive_treatment.aspx?id=23117

RE: [cml 2] My Latest Test

2008-05-08 12:55:18

Way to go Margot. That is such great news. This is as good as it gets. I'm
right behind you. Had CML for 7 years and only recently hit PCRU. Like you,
no side effects to complain about.
Zavie

Low dose of IM - Cam

2008-05-07 22:21:13

Cam,
It is possible that due to a slowed metabolism or some other mechanism, you
could be achieving a therapeutic serum level if IM (Gleevec) on 200mg/ day.
In that case you're at no greater risk of resistance than are those of us
who take 400mg/day. Not only that, but you'd be achieving the same efficacy
at half the cost and, potentially, half the side effects!
Moreover, I know of no actual evidence that taking less than the standard
dose of IM (Gleevec) causes resistance. HOWEVER (and this is a big
however), if your IM serum level is sub-therapeutic, there are still strong
theoretical reasons to be concerned that resistance could become a problem
over time.
When IM was first approved, Novartis asserted that serum levels hardly
varied from patient to patient, and for this reason (and probably others
which they haven't revealed) they have refused, until recently, to make
their test for IM serum level available. A number of senior CML researchers,
including Brian Druker, feel this is misguided, and I agree, Fortunately, I
gather that recently Novartis has indeed released the test to some centers,
but it's my opinion that the test should be made available to ALL patients
who can't tolerate standard doses (and also for patients who experience a
suboptimal response at 400mg. It may be that a subset of these patients
just don't get enough of the drug into their bloodstream, rather than having
resistant or insensitive CML cells. If the former, there are probably safer
and easier ways to achieve therapeutic levels than doubling the IM dose - so
for in these cases too, serum levels would be desirable). Anyway, you might
find out whether your doctor has access to the newly available serum levels.
If so, and you could determine that your IM serum level was therapeutic on
200 mg, then you'd be home free on that dose.
It's more likely that this is not the case, however, and that you simply
can't tolerate 400 mg. Two other options are still available to you if
that's the case. The more conventional and almost certainly the preferable
one would be a switch to Sprycel.
If you couldn't tolerate this drug either though, you might then consider a
pulse regimen, which might well be just as tolerable as a continuous low
dose such as you're now on, and (I firmly believe) more effective and safer.
Here's how, if I were in your shoes and in control of my own management, I
would go about designing such a regimen:
First, I'd stop IM altogether and follow weekly CBCs until my blood counts
(red or white, whichever are most troublesomely suppressed) rebounded to a
reasonable level. Then I'd restart at 400mg and continue until the counts
dropped too far, then stop again. I would repeat cycle this AS LONG AS I
could stay on IM for at least one, and preferably two months at a time ---
AND as long as I were regularly able to keep my breaks to six weeks or less.
Treatment periods less than a month might be to short to kill leukemia
cells, while drug holidays longer than 6 weeks might give the disease long
long enough to start relapsing.
So there you have my two bits. I hope you find them useful - or at least
interesting!
Richard R

Re: [cml 2] My Latest Test--Margo

2008-05-07 20:22:18

Dear Margot,
What a wonderful post for all of us to read and ponder and especially the
newbies. I'm so happy to hear your results. The newbies should also take note
that you were patient and did not send your labs to Texas during the holidays.
It's such a pain to have to go through labs twice -- not the least of which is
the worry until you figure out that the labs were compromised. Happy New Year!
Now we're in the Age of Sprycel, too!
Best regards,
Susan L

Re: My Latest Test

2008-05-07 20:13:31

You're an inspiration to all of us Margot. Thanks so much for
posting this and may you have many more years of great health.
Tracey

My Latest Test

2008-05-07 10:44:05

Just thought I'd let you all know that my latest tests came out totally
negative again, the ABL-BCR test as well as the PCR (100,000 cells) test. I
had the blood tests taken just before Christmas and did not ask for them to
be sent to MDACC because of the holidays. I was sure they'd be all messed
up by sending them away over that time period.
By the time March 23 comes around I will have had CML for nine years and
have been PCRU since January 2002. Something for the newbies to think about
For those who have been diagnosed in the Gleevec age, it wouldn't have
taken four years to become PCRU, but that was the "olden" days when the
diagnosis still gave you an outlook of 3 to 5 years as your future life span
on Interferon. And I might add for the benefit of those who were more
recently diagnosed, that I have few side effects and they happen only
occasionally, so that I tend to mostly ignore them.
Margot

Re: [cml 2] Digest Number 604

2008-05-06 22:09:29

Hey Group:
After 800,000+ and my 2-5 months morbid mortality; I am now taking 400 mg.,
downplaying my side effects and a Survivor. I don't recommend 'gold
holidays'/pulsing to anyone; going to the 2nd generation medications; or being
'in search of a cure'. . .
I cannot stress enough that each of us is a statistic; but also an individual
in our survival.
Wendy, your better 1/2 had 1/2 the 'bad' I had at diagnosis, another sister
survivor has numerous other Chronic illnesses as I do, and Cam's trying to find
his 'niche' for dosage as I did. Been there/done that!
I know that ALL of my Newbie Sister & Brother Survivors will be 'CML Alive &
Kicking'. . . living the Gold life. You all just have to be patient and let your
body's adjust to the gold. . . believe me it takes time. Over 3 years ago as I
bent over the toilet bowl, hardly able to get there due to the edema all
over--my severe pain from my Chronic Ortho issues; in & out of the ER/hospital
admissions, 2 heart attacks, other chronic illnesses diagnosed. . . I went
thr